ITC & NMA
Indirect treatment comparison and network meta-analysis.
When you don't have a head-to-head trial, ITCs and NMAs estimate relative effects across a network of trials connected by a common comparator.
Indirect treatment comparisons (ITCs) estimate relative effects between treatments that were never compared head-to-head, by linking them through a common comparator. A network meta-analysis (NMA) generalises this across a connected network of trials. Where networks don't connect, an anchored or unanchored MAIC can adjust for population differences using individual patient data.
Reviewers care about: assumption of consistency, transitivity, choice of effect modifiers, and whether you've pre-registered the analysis. Unanchored MAICs face the highest scrutiny.
A markdown template covering PICO, eligibility, effect modifiers, choice of method, sensitivity analyses and reporting — drop into your study folder.
Structured search across PubMed, Embase, congress abstracts and HTA decisions, deduplicated and screened with reviewer-grade criteria.
Scaffold anchored and unanchored MAICs, NMAs and standard ITCs — assumptions tracked, sensitivity pre-run, code your ERG or IQWiG can reproduce.